How We Ranked These
Peptides are ranked here by quality and quantity of relevant evidence — prioritizing human clinical data where it exists, then animal models, with anecdotal reports noted but not used for ranking. We also consider legal status and practical accessibility.
Tier 1: Strong Evidence (Human Trials)
Sermorelin and semaglutide both have significant human trial data relevant to body composition. While semaglutide is primarily studied for fat loss, its lean mass preservation effects are documented. Thymosin Alpha-1 has human data for immune support that may complement recovery in immunocompromised individuals.
Tier 2: Strong Animal Evidence, Limited Human Data
BPC-157 and TB-500 both have compelling animal research for tissue repair and recovery. The animal data is extensive and mechanistically plausible, but neither has completed human trials specifically for muscle recovery. CJC-1295 has human trial data for GH elevation, with body composition as a secondary endpoint.
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Tier 3: Emerging and Experimental
Ipamorelin, MK-677, and MOTS-c round out the list. Ipamorelin and MK-677 have limited human data on GH elevation. MOTS-c is the most experimental — compelling animal data, essentially no human trial data yet.